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Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, J. He, Wei-Jun Zhang, Xiao-Xiao Zhao, Bi-Qing Liu, Yonghong Zhou, Xiao-Jiang |
| Copyright Year | 2015 |
| Abstract | A new dimeric sesquiterpene, dicarabrol (1), together with three known sesquiterpenes, carabrol (2), 11(13)-dehydroivaxillin (3), and 2-desoxy-4-epi-pulchellin (4), were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic analysis, and single crystal X-ray diffraction analysis. Compound 1 possessed a dimeric sesquiterpene core featured with a cyclopentane ring connecting two sesquiterpene lactone units rarely discovered in nature. Dicarabrol (1), as well as three known sesquiterpenes (2-4), had potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7 μM, while they showed significant antiviral (H1N1 and H3N2) activities. Furthermore, compounds 1, 3 and 4 displayed significant antimycobacterial activity (IC50 3.7, 6.0, and 7.6 μM, respectively). |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.bmcl.2015.08.034 |
| Alternate Webpage(s) | http://ir.scsio.ac.cn/bitstream/344004/14766/1/Dicarabrol,%20a%20new%20dimeric%20sesquiterpene%20from%20Carpesium%20abrotanoides%20L..pdf |
| PubMed reference number | 26316467 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.bmcl.2015.08.034 |
| Journal | Medline |
| Volume Number | 25 |
| Issue Number | 19 |
| Journal | Bioorganic & medicinal chemistry letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
