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Spectrophotometric Determination of Thymol in Pharmaceutical Preparation via Diazotization Reaction with 4-aminoacetophenone
| Content Provider | Semantic Scholar |
|---|---|
| Author | Al-Ramadhani, Salih T. |
| Copyright Year | 2014 |
| Abstract | A simple and sensitive spectrophotometric method is proposed for the determination of thymol. The method is based on the coupling reaction of the drug with diazotised 4aminoacetophenone reagent in alkaline medium to produce an intense red coloured water soluble and stable azo dye which exhibits a maximum absorption at 502 nm. Beer's low is obeyed over the concentration range 0.2 – 16 μg/ml with a molar absorptivity of 2.89×10 L.mol.cm. The limit of detection is 0.0216 μg/ml and the limit of quantitation is 0.072 μg/ml, average recovery is 101.6%, and RSD is less than 2.4%. The proposed method is applied successfully to the determination of thymol in pharmaceutical preparation. |
| Starting Page | 44 |
| Ending Page | 56 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Volume Number | 25 |
| Alternate Webpage(s) | https://www.iasj.net/iasj?aId=88567&func=fulltext |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
