The Multifaceted Role of Interferon-γ in Central Nervous System Autoimmune Demyelination~!2009-09-01~!2009-11-02~!2010-07-14~!

Content Provider	Semantic Scholar
Author	Sanvito, Lara
Copyright Year	2010
Abstract	Extensive research has been devoted to the study of IFN-� function in several autoimmune diseases. Previously considered the hallmark of Th1 differentiation and pro-inflammatory responses, it has soon become evident that this piv- otal cytokine plays a much more complex role than initially thought. These considerations have been particularly relevant to the understanding of the pathogenesis of autoimmune demyelination of the central nervous system (CNS). Evidence of the multifaceted effects of IFN-� in this disease has been gathered mainly by studies in the animal model, experimental autoimmune encephalomyelitis (EAE). In this review we summarize the fundamental steps and examine the possible fac- tors involved in the apparent dichotomy between pro-inflammatory and protective effects of IFN-� in CNS autoimmune demyelination. A clear understanding of the heterogeneous functions of this key cytokine is paramount in order to fully explore the potential of manipulation of its pathways for the treatment of Multiple Sclerosis.
Starting Page	151
Ending Page	159
Page Count	9
File Format	PDF HTM / HTML
DOI	10.2174/1876894601002040151
Volume Number	2
Alternate Webpage(s)	https://benthamopen.com/contents/pdf/TOAUTOJ/TOAUTOJ-2-151.pdf
Alternate Webpage(s)	http://benthamopen.com/contents/pdf/TOAUTOJ/TOAUTOJ-2-151.pdf
Alternate Webpage(s)	http://www.bentham-open.com/contents/pdf/TOAUTOJ/TOAUTOJ-2-151.pdf
Alternate Webpage(s)	https://doi.org/10.2174/1876894601002040151
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article