Loading...
Please wait, while we are loading the content...
Similar Documents
Mechanical Unloading with Left Ventricular Assist Device after Acute Myocardial Infarction Prevents Adverse Cardiac Remodeling
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wei, Xufeng |
| Copyright Year | 2012 |
| Abstract | Methods: Adult Dorsett hybrid sheep were unloaded with a LVAD (Impella pump) for 2 weeks after acute MI and analyzed for 10 following weeks (n=8). Eight sheep with MI only and four sham sheep were used as controls. Regional diastolic and systolic strains of the left ventricle (LV) were measured by sonomicrometry array localization. The infarction size was measured at necropsy and digitalized as a ratio of infarcted scar area to the LV free wall. Apoptosis, hypertrophy, and ultrustructural damage were investigated in non-ischemic adjacent zone and remote zone to MI. Proteins involved in the mitochondrial apoptotic pathway (Calcineurin/BAD) and the pro-hypertrophic raf/MEK/ERK pathway were studied by western blotting. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/s0735-1097(12)60859-6 |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/81214335.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/s0735-1097%2812%2960859-6 |
| Volume Number | 59 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |