NDLI: Synthesis of 4-substituted oxazolo[4,5-c]quinolines by direct reaction at the C-4 position of oxazoles.

Content Provider	Semantic Scholar
Author	Akula, Mahesh Thigulla, Yadagiri Davis, Connor Race Jha, Mukund Bhattacharya, Anupam
Copyright Year	2015
Abstract	A facile synthesis of 4-aryl substituted oxazolo[4,5-c]quinolines has been described via a modified Pictet-Spengler method and using Cu(TFA)2 as a catalyst. The developed methodology directly functionalizes the C-4 position of oxazoles without the aid of any prefunctionalization, in the presence of the more reactive C-2 position in good yields. The versatility of the established method has been demonstrated by its application in the synthesis of 4-substituted oxazolo-[1,8]naphthyridine ring systems.
File Format	PDF HTM / HTML
DOI	10.1039/c4ob02224f
PubMed reference number	25574832
Journal	Medline
Volume Number	13
Issue Number	9
Alternate Webpage(s)	http://www.rsc.org/suppdata/ob/c4/c4ob02224f/c4ob02224f1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c4ob02224f
Journal	Organic & biomolecular chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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