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Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mokoka, Tsholofelo Abednego Peter, X. Ma Fouche, Gerda Moodley, Nivan Adams, Michael Q. Hamburger, Matthias Kaiser, Marcel Brun, Reto Maharaj, Vinesh J. Koorbanally, Neil Anthony |
| Copyright Year | 2014 |
| Abstract | In South Africa, Salvia repens is used traditionally to treat sores, stomach ache and diarrhoea. The high performance liquid chromatography (HPLC)-based activity profiling of S. repens whole plant extract showed an active abietane diterpene, identified as 12-methoxycarnosic acid (1) which showed antiprotozoal activity against axenically grown Leishmania donovani amastigotes with an IC50 of 0.75 μM with marginal cytotoxicity against the L6-cells (IC50, 17.3 μM). |
| Starting Page | 93 |
| Ending Page | 95 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.sajb.2013.10.014 |
| Volume Number | 90 |
| Alternate Webpage(s) | http://researchspace.csir.co.za/dspace/bitstream/handle/10204/7354/Mokoka_2014.pdf?isAllowed=y&sequence=3 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.sajb.2013.10.014 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |