Apoptosis in acute and chronic neurological disorders.

Content Provider	Semantic Scholar
Author	Ekshyyan, Oleksandr Y. Aw, Tak Yee
Copyright Year	2004
Abstract	Programmed cell death or apoptosis is a physiologically important process in neurogenesis wherein approximately 50% of the neurons apoptose during maturation of the nervous system. However, premature apoptosis and/or aberrations in apoptosis control contribute to the pathogenesis of a variety of neurological disorders including acute brain injury such as trauma, spinal cord injury, ischemic stroke and ischemia/reperfusion as well as chronic disease states such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, spinal muscular atrophy, and diabetic neuropathy. The current review will focus on two major topics, namely, the general concepts of our current understanding of the apoptosis death machinery, its mediators and regulation, and the relationship between aberrant apoptosis and genesis of neurodegenerative disorders. This knowledge of apoptosis mechanisms will underpin the basis for development of novel therapeutic strategies and treatment modalities that are directed at control of the neuronal apoptotic death program.
Starting Page	26008
Ending Page	26012
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.bioscience.org/fbs/getfile.php?FileName=/2004/v9/af/1357/1357.pdf
PubMed reference number	14977568v1
Volume Number	9
Journal	Frontiers in bioscience : a journal and virtual library
Language	English
Access Restriction	Open
Subject Keyword	Amyotrophic Lateral Sclerosis Anatomical maturation Apoptosis Brain Injuries CNS disorder Cell Death Cerebral Infarction Cessation of life Chronic disease Diabetic Neuropathies Hypoxia-Ischemia, Brain Injuries, Acute Brain Juvenile Spinal Muscular Atrophy Muscle Neurodegenerative Disorders Neurogenesis Parkinsonian Disorders Reperfusion Therapy Spinal Cord Injuries Vocal Cord Paralysis Wounds and Injuries nervous system disorder
Content Type	Text
Resource Type	Article