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Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, γ-acetylenic GABA (4-amino-hex-5-ynoic acid) and γ-vinyl GABA (4-amino-hex-5-enoic acid)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Meldrum, Brian S. Horton, Roger W. |
| Copyright Year | 2004 |
| Abstract | The anticonvulsant potency and neurological toxicity of two new catalytic inhibitors of GABA-transaminase have been assessed in acute experiments in baboons with a natural syndrome of photic epilepsy. γ-Acetylenic GABA, 160–200 mg/kg, or γ-vinyl GABA, 450–950 mg/kg, intravenously, gave complete protection against generalised myoclonus or seizure responses induced by photic stimulation (in baboons without or with priming with subconvulsant doses of allyglycine). The protection became maximal 1–3 h after injection, and continued for 7–24 h. Signs characteristic of the acute toxicity of anticonvulsant drugs (nystagmus and ataxia) were not seen. The potential use of these compounds in human epilepsy deserves investigation. |
| Starting Page | 47 |
| Ending Page | 50 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/BF00428029 |
| PubMed reference number | 100812 |
| Journal | Medline |
| Volume Number | 59 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/BF00428029 |
| Alternate Webpage(s) | https://doi.org/10.1007/BF00428029 |
| Journal | Psychopharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
