NDLI: Hormonal Regulation of GnRH and LHβ mRNA Expression in Cultured Rat Granulosa Cells

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Hormonal Regulation of GnRH and LHβ mRNA Expression in Cultured Rat Granulosa Cells

Content Provider	Semantic Scholar
Author	Litichever, Naomi Gershon, Eran Dekel, Nava Koch, Yitzhak
Copyright Year	2009
Abstract	We have recently demonstrated that the rat ovary expresses LHβ, FSHβ, and the common alpha subunit mRNA. In the present report, we studied the regulation of LHβ and of gonadotropin-releasing hormone (GnRH) mRNA expression in granulosa cells that were isolated from immature rats treated with either estrogen or pregnant mare serum gonadotropin (PMSG). In both cell types, GnRH agonist treatment resulted in a decrease in LHβ mRNA expression. However, only in cells derived from PMSG-treated rats, GnRH treatment produced an increase in GnRH mRNA expression. A markedly increased GnRH mRNA expression was also obtained in granulosa cells derived from PMSG-primed rats in response to LH. In addition, FSH reduced the expression of LHβ mRNA in granulosa cells from estrogen-primed rats. These results suggest that the expression of LHβ in the ovary is regulated by locally produced GnRH and by FSH from either the ovary or the pituitary.
Starting Page	78
Ending Page	85
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1007/s12031-009-9185-8
PubMed reference number	19253008
Journal	Medline
Volume Number	39
Alternate Webpage(s)	http://www.weizmann.ac.il/Biological_Regulation/Dekel/sites/Biological_Regulation.Dekel/files/naomi2009.pdf
Journal	Journal of Molecular Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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