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Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gieffers, Jens Reusche, Erich Solbach, Wilfried Maass, Matthias |
| Copyright Year | 2000 |
| Abstract | A recent North American study detected Chlamydia pneumoniae in 17 of 19 brains of Alzheimer's patients and supposed a C. pneumoniae infection to be a risk factor for Alzheimer's disease (AD). In this study, we analyzed paraffin-embedded tissue samples of 20 AD patients by nested PCR and immunocytochemistry with a panel of antichlamydial antibodies and could detect neither C. pneumoniae-specific DNA nor chlamydial antigens. From our data, the presence of C. pneumoniae in the brains of Alzheimer's patients is not a common phenomenon; an association remains questionable. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/jcm.38.2.881-882.2000 |
| PubMed reference number | 10655406 |
| Journal | Medline |
| Volume Number | 38 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://jcm.asm.org/content/38/2/881.full.pdf |
| Journal | Journal of clinical microbiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |