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Integrated electrodes on a silicon based ion channel measurement platform.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wilk, S. J. Petrossian, Leo Goryll, Michael Thornton, Trevor J. Goodnick, Stephen M. Tang, J. M. Eisenberg, Robert S. |
| Copyright Year | 2007 |
| Abstract | We demonstrate the microfabrication of a low-noise silicon based device with integrated silver/silver chloride electrodes used for the measurement of single ion channel proteins. An aperture of 150 microm diameter was etched in a silicon substrate using a deep silicon reactive ion etcher and passivated with 30 nm of polytetrafluoroethylene via chemical vapor deposition. The average recorded noise in measurements of lipid bilayers was reduced by a factor of four through patterning of a 75 microm thick SU-8 layer around the aperture. Integrated electrodes were fabricated on both sides of the device and used for repeatable, stable, giga-seal bilayer formations as well as characteristic measurements of the transmembrane protein OmpF porin. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.bios.2007.03.030 |
| PubMed reference number | 17507211 |
| Journal | Medline |
| Volume Number | 23 |
| Issue Number | 2 |
| Alternate Webpage(s) | https://ftp.rush.edu/users/molebio/Bob_Eisenberg/Reprints/2007/Wilk_BB_2007.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.bios.2007.03.030 |
| Journal | Biosensors & bioelectronics |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
