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Identification of a BglI polymorphism of catechol-O-methyltransferase (COMT) gene, and association study with schizophrenia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chen, C. H. Wei, Feng Cai Koong, F. J. Hwu, Hai-Gwo Hsiao, K. J. |
| Copyright Year | 1996 |
| Abstract | Several linkage studies suggested chromosome 22q11-13 may harbor susceptible genes for schizophrenia. Catechol-O-methyl-transferase (COMT), which is involved in the metabolism of catecholamines, was mapped to 22q11 and is considered a possible candidate gene for schizophrenia. Recently, we identified a polymorphic marker, a single nucleotide C insertion at the 3' untranslated region of the COMT gene, which obliterates a BglI site. Using this BglI polymorphism, we conducted a case-control association study in Chinese patients with schizophrenia. No significant differences of allele and genotype frequencies were noted between patients (N = 177) and controls (N = 99). When patients were subgrouped according to sex, no significant differences of genotype and allele frequencies were noted in either male or female patients compared to normal controls. Our results do not support an association between the BglI polymorphism of COMT gene and schizophrenia. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 8950414 |
| Journal | Medline |
| Volume Number | 67 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://ntur.lib.ntu.edu.tw/bitstream/246246/172894/1/13.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/%28SICI%291096-8628%2819961122%2967%3A6%3C556%3A%3AAID-AJMG8%3E3.0.CO%3B2-F |
| Journal | American journal of medical genetics |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
