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Atypical antipsychotic clozapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of DOI into the inferior colliculus in rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Oliveira, Rodolpho Pereira De Nagaishi, Karen Yuriko Silva, Regina Cláudia Barbosa |
| Copyright Year | 2017 |
| Abstract | HighlightsUnilateral microinjections of DOI, a 5HT2 agonist, into the inferior colliculus (IC) disrupted PPI.Microinjections of ritanserin into the IC did not alter PPI.Pretreatment with clozapine blocked DOI‐induced disruption of PPI.These results suggest that serotonergic neurotransmission of the IC can be involved in the mediation of PPI in rats. Abstract Dysfunctions of the serotonergic system have been suggested to be important in the neurobiology of schizophrenia. Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low intensity non‐startling stimulus (prepulse) which is presented shortly before the startle stimulus (pulse). The hallucinogen 2,5‐dimethoxy‐4‐iodoamphetamine (DOI), a 5‐hydroxytryptamine(HT)2 receptor agonist disrupted PPI in rats. The inferior colliculus (IC) is a critical nucleus of the auditory pathway mediating acoustic PPI. The activation of the IC by the acoustic prepulse reduces startle magnitude. The present study investigated the role of serotonergic transmission in the IC on the expression of acoustic PPI. For that we investigated whether 5‐HT2A receptor activation or blockade would affect this response. Unilateral microinjection of DOI (10 &mgr;g/0.3 &mgr;l) into the IC disrupted PPI, while microinjection of the 5‐HT2A receptor antagonist ritanserin (4 &mgr;g/0.3 &mgr;l), into this structure did not alter PPI. We also examined the ability of the atypical antipsychotic clozapine (5.0 mg/kg; I.P.) to reverse the disruption of PPI produced by unilateral microinjections of DOI into the IC of rats. Pretreatment with clozapine blocked DOI‐induced disruption of PPI. Altogether, these results suggest that serotonin‐mediated mechanisms of the IC are involved in the expression of PPI in rodents and that this response is sensitive to atypical antipsychotic clozapine. |
| Starting Page | 72 |
| Ending Page | 78 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.bbr.2017.01.053 |
| PubMed reference number | 28202410 |
| Journal | Medline |
| Volume Number | 325 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S016643281631021X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S016643281631021X?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.bbr.2017.01.053 |
| Journal | Behavioural Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
