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Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Borel, Patrick Moussa, Myriam Reboul, Emmanuelle Lyan, Bernard Defoort, Catherine Vincent-Baudry, Stéphanie Maillot, Matthieu Gastaldi, Marguerite Darmon, Michel Portugal, Henri Planells, Richard Lairon, Denis |
| Copyright Year | 2007 |
| Abstract | Vitamin E and carotenoids are fat-soluble micronutrients carried by plasma lipoproteins. Their plasma concentrations are governed by several factors, some of which are genetic, but data on these genetic factors remain scarce. We hypothesized that genes involved in lipid metabolism, i.e. the genes implicated in intestinal uptake, intracellular trafficking, and the lipoprotein distribution of lipids, play a role in the plasma concentrations of these micronutrients. To verify this hypothesis, we assessed whether the plasma status of vitamin E and carotenoids is related to genes involved in lipid metabolism. Fasting plasma vitamin E (alpha- and gamma-tocopherol) and carotenoid (alpha- and beta-carotene, lutein, lycopene, beta-cryptoxanthin, and zeaxanthin) concentrations were measured in 48 males and 80 females. The following genes were genotyped [single nucleotide polymorphisms (SNP)]: apolipoprotein (apo) A-IV, apo B, apo E, lipoprotein lipase, and scavenger-receptor class B type I (SR-BI). Plasma alpha-tocopherol concentrations were different (P < 0.05) in subjects bearing different SNP in apo A-IV, apo E, and SR-BI. Plasma gamma-tocopherol concentrations were different (P < 0.05) in subjects bearing different SNP in apo A-IV and SR-BI. Alpha-carotene concentrations were different (P < 0.05) in subjects bearing different SNP in SR-BI. Beta-carotene concentrations were different (P < 0.05) in subjects bearing different SNP in apo B and SR-BI. Lycopene concentrations were different (P < 0.05) in subjects bearing different SNP in apo A-IV and apo B. Beta-cryptoxanthin concentrations were different (P < 0.05) in subjects bearing different SNP in SR-BI. Plasma lutein and zeaxanthin concentrations did not differ in subjects bearing different SNP. Most of the differences remained significant after the plasma micronutrients were adjusted for plasma triglycerides and cholesterol. These results suggest that genes involved in lipid metabolism influence the plasma concentrations of these fat-soluble micronutrients. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spectracell.com/media/uploaded/0/0e2029479_066abstract2007jnutrvitamineandgeneticpolymorphismsinlipidmetabolismpdf-.pdf |
| PubMed reference number | 18029479v1 |
| Volume Number | 137 |
| Issue Number | 12 |
| Journal | The Journal of nutrition |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adipocytes, Beige Adrenergic beta-Agonists Apolipoprotein E Apolipoproteins A Apolipoproteins B Beta Carotene Beta-Cryptoxanthin Carotenoids Cholesterol Cryptoxanthins Eighty Gas Scavengers Genetic Polymorphism LIPOPROTEIN LIPASE Lipid Metabolism Disorders Lipoproteins Lutein Micronutrients Nitroprusside Platelet Glycoprotein 4, human Single Nucleotide Polymorphism Triglycerides Vitamin E alpha-Mannosidosis gamma-Tocopherol lycopene zeaxanthin |
| Content Type | Text |
| Resource Type | Article |
