NDLI: Day-night differences in estimated rates of 5-hydroxytryptamine turnover in the rat pineal gland

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Day-night differences in estimated rates of 5-hydroxytryptamine turnover in the rat pineal gland

Content Provider	Semantic Scholar
Author	King, Terry S. Steger, Richard W. Steinlechner, Stephan Reiter, Russel J.
Copyright Year	2004
Abstract	SummaryRates of 5-hydroxytryptamine synthesis in various brain tissues can be estimated from the linear increase in 5-hydroxytryptophan levels following inhibition of 5-hydroxytryptophan decarboxylation with RO4-4602 or NSD-1015. In addition, NSD-1015 can prevent 5-hydroxytryptamine oxidative-deamination via monoamine oxidase inhibition, leading to linear decreases in a major metabolite of this amine, 5-hydroxyindole acetic acid. In the rat pineal gland we demonstrated similar increases in 5-hydroxytryptophan levels after nocturnal or diurnal injection of RO4-4602 (100 mg · kg−1) or NSD-1015 (200 mg · kg−1). Similar decreases in 5-hydroxyindole acetic acid were also observed after nocturnal or diurnal injection of NSD-1015 or pargyline (an inhibitor of monoamine oxidase) (75 mg · kg−1). 5-Hydroxytryptamine levels increased after nocturnal pargyline injection but remained constant after diurnal pargyline administration. 5-Hydroxytryptamine levels exhibited little change following nocturnal injection of NSD-1015 but decreased linearly after diurnal injection of NSD-1015. We suggest that (1) rat pineal 5-hydroxytryptamine synthesis is increased nocturnally, (2) metabolic utilization, primarily by oxidative-deamination, of 5-hydroxytryptamine is increased diurnally and (3) basal levels of pineal 5-hydroxytryptamine may be stored within adrenergic nerve endings which innervate the pinealocytes responsible for synthesizing this amine, thus “protecting” or otherwise making unavailable this pool of 5-hydroxytryptamine for metabolic utilization.
Starting Page	432
Ending Page	436
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1007/BF00235468
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/BF00235468
PubMed reference number	6539225
Alternate Webpage(s)	https://doi.org/10.1007/BF00235468
Journal	Medline
Volume Number	54
Journal	Experimental Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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