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The pan-histone deacetylase inhibitor LBH589 (panobinostat) alters the invasive breast cancer cell phenotype.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fortunati, Nicoletta Marano, Francesca Bandino, Andrea Frairia, Roberto Catalano, Maria Graziella Boccuzzi, Giuseppe |
| Copyright Year | 2014 |
| Abstract | Triple-negative breast cancer (TNBC) is a very aggressive type of tumour and its aggressiveness is linked to E-cadherin downregulation. In estrogen-sensitive breast cancer, high levels of E-cadherin fit with high levels of ERα and MTA3 (a component of the transcription Mi-2/NuRD complex with intrinsic DAC activity). In TNBC the E-cadherin downregulation could be due to epigenetic silencing of the CDH1 gene as well as to the lack of a fully functioning ERα-activated pathway. We report that the pan-histone deacetylase inhibitor LBH589, a potent anti-proliferative agent, induced E-cadherin expression on cell membranes of MDA-MB-231 cells (TNBC), determining a reduction of cell invasion and migration. Even though E-cadherin expression in breast cancer is also regulated by estradiol and the ERα/MTA3/Snail/Slug pathway, LBH589 is able to increase E-cadherin without affecting the estrogen pathway. In fact, no expression of ERα, PR and FoxA1 was observed in MDA-MB-231 cells before and after LBH589 treatment; furthermore, the drug caused an increase in Snail and Slug expression with a concomitant reduction of MTA3 levels. Taking into consideration its anti-proliferative and anti-invasive properties, we suggest the use of LBH589 in aggressive breast cancer refractory to hormonal therapy. |
| File Format | PDF HTM / HTML |
| DOI | 10.3892/ijo.2013.2218 |
| PubMed reference number | 24366407 |
| Journal | Medline |
| Volume Number | 44 |
| Issue Number | 3 |
| Journal | International journal of oncology |
| Alternate Webpage(s) | https://iris.unito.it/retrieve/handle/2318/142652/23325/Int%20J%20Oncol%20Early%20Online%20ijo.2013.2218.pdf |
| Alternate Webpage(s) | https://www.spandidos-publications.com/ijo/44/3/700/download |
| Alternate Webpage(s) | https://doi.org/10.3892/ijo.2013.2218 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
