NDLI: Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music.

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Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music.

Content Provider	Semantic Scholar
Author	Dreisbach, Laura Elizabeth Lockwood, Jill Baldwin, Kristy Scranton, Shawn
Copyright Year	2006
Abstract	Antioxidants have been reported to be effective in reducing acoustic trauma in animal models but have not been studied in humans. In this study, the antioxidant N-acetylcysteine (NAC) was evaluated to determine if it would reduce temporary changes in auditory function as a result of exposure to loud music in humans. Pure-tone thresholds and distortion product otoacoustic emissions (DPOAEs) were collected in 31 normal-hearing participants, using a randomized, double-blind, placebo-controlled design, before and after two hours of live music in a nightclub. Using repeated measures analysis of variance, no statistically significant differences were found between participants who received NAC versus a placebo for any of the outcome measures. Across all subjects, the largest pure-tone threshold shift occurred at 4 kHz. DPOAE measures were characterized by reductions in amplitude and a trend for shorter group delay values. When the 3 and 4 kHz data were examined by imposing specific criteria of greater than 2 dB DPOAE amplitude reductions and 10 dB or greater pure-tone threshold shifts, DPOAE reductions occurred more often at 3 kHz, and pure-tone shifts occurred more often at 4 kHz.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.audiology.org/sites/default/files/journal/JAAA_17_04_04.pdf
Alternate Webpage(s)	http://www.audiology.org/sites/default/files/journal/JAAA_17_04_04.pdf
PubMed reference number	16761701v1
Volume Number	17
Issue Number	4
Journal	Journal of the American Academy of Audiology
Language	English
Access Restriction	Open
Subject Keyword	Acetylcysteine Acoustic Trauma Animal Model Antioxidants EPRS gene Ear structure Emission - Male genitalia finding Evoked Otoacoustic Emissions, Screening Assessment using Otoacoustic Emission (OAE) Equipment Hearing Kilohertz Otoacoustic Emissions, Spontaneous Sample Variance Wounds and Injuries
Content Type	Text
Resource Type	Article

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