NDLI: [Effects of Pollen Typhae total flavone on glucose and lipid metabolism in 3T3-L1 adipocytes].

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[Effects of Pollen Typhae total flavone on glucose and lipid metabolism in 3T3-L1 adipocytes].

Content Provider	Semantic Scholar
Author	He, Yan-Ming Wang, Wenjian Chen, Weihua Ying, Jian He, Chun-Yan Li, You-Shen
Copyright Year	2006
Abstract	OBJECTIVE To observe the effects of Pollen Typhae total flavone (PTF) on glucose and lipid metabolism in 3T3-L1 adipocytes. METHODS The content of glucose which disappeared from the culture medium after incubation with drugs for 24 hours was determined as glucose consumption of the cells. The activity of cells was detected by XTT method. The transport of glucose was observed by (3)H-glucose uptake method. The efflux of free fatty acid (FFA) from adipocytes was observed by the concentration of FFA in the culture medium. RESULTS The glucose concentration in culture medium was significantly decreased with a concentration-dependent effect, when PTF concentrations were from 0.025 g/L to 0.4 g/L. The toxic effect on cells appeared while PTF concentration was 0.4 g/L, and the MTT value decreased. PTF also significantly increased glucose transportation in the 3T3-L1 adipocytes as rosiglitazone (ROS) did. At the same time, FFA concentration in culture medium was significantly decreased as compared to the normal control group, while ROS-treated group did not show any difference. CONCLUSION PTF can increase insulin sensitivity by increasing glucose transportation and consumption in the 3T3-L1 adipocytes as well as decreasing the FFA efflux from the cells.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jcimjournal.com/articles/publishArticles/pdf/20061122789482134.pdf
PubMed reference number	17090374v1
Volume Number	4
Issue Number	6
Journal	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Language	English
Access Restriction	Open
Subject Keyword	Adipocytes Culture Media Hydrogen Lipid Metabolism Disorders Nonesterified Fatty Acids Pollen flavone glucose uptake insulin, isophane monooxyethylene trimethylolpropane tristearate rosiglitazone
Content Type	Text
Resource Type	Article

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