NDLI: Interaction between Trichomonas vaginalis and the Prostate Epithelium

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Interaction between Trichomonas vaginalis and the Prostate Epithelium

Content Provider	Semantic Scholar
Author	Kim, Jung-Hyun Han, Ik-Hwan Kim, Sang-su Suwon Park, Soon-Jung Min, Duk-Young Kim, Sung Woo Ryu, Jae-Sook
Copyright Year	2017
Abstract	Most men infected with Trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. This has been hypothesized to result in chronic persistent prostatic infection. Adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for T. vaginalis infection. Adhesion of T. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by T. vaginalis. The aim of this study was to investigate whether adhesion and cytotoxicity of T. vaginalis are involved in inflammation of prostate epithelial cells. When RWPE-1 cells were infected with T. vaginalis (1:0.4 or 1:4), adhesion of T. vaginalis continuously increased for 24 hr or 3 hr, respectively. The cytotoxicity of prostate epithelial cells infected with T. vaginalis (RWPE-1: T. vaginalis=1:0.4) increased at 9 hr; at an infection ratio of 1:4, cytotoxicity increased after 3 hr. When the RWPE-1 to T. vaginalis ratio was 1:0.4 or 1:4, production of IL-1β, IL-6, CCL2, and CXCL8 also increased. Epithelial-mesenchymal transition (EMT) was verified by measuring decreased E-cadherin and increased vimentin expression at 24 hr and 48 hr. Taken together, the results indicate that T. vaginalis adhered to prostate epithelial cells, causing cytotoxicity, pro-inflammatory cytokine production, and EMT. Our findings suggest for the first time that T. vaginalis may induce inflammation via adhesion to normal prostate epithelial cells.
Starting Page	213
Ending Page	218
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	28506046v1
Alternate Webpage(s)	https://doi.org/10.3347/kjp.2017.55.2.213
DOI	10.3347/kjp.2017.55.2.213
Journal	The Korean journal of parasitology
Volume Number	55
Language	English
Access Restriction	Open
Subject Keyword	Cadherins Carcinoma Epithelial Cells Inflammation Mucous Membrane Prostatic Neoplasms Protozoa Trichomonas vaginalis cytokine prostate infection
Content Type	Text
Resource Type	Article

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