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Age-Associated Osmoregulatory Alterations in Thirst, Drinking Pattern and Arginine Vasopressin Secretion in Man
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mazi, Ikechukwu Amabebe, Emmanuel Igbokwe, Vincent U. Obika, Leonard Fedinard |
| Copyright Year | 2019 |
| Abstract | We examined the renal, hormonal and central thirst and arginine vasopressin (AVP) osmoregulatory systems that accompany the aging process and how these influence the risk of altered water and electrolyte balance in the elderly. When deprived of fluid or confronted with a hyperosmotic or hypovolemic stimulus, elderly people exhibit a decreased perception of thirst and reduced fluid intake. Altered hydromineralbalance is a common feature in elderly people due to impaired capacity to restore and maintain fluid balance. The consequent hypovolemia appears to be induced by decreased thirst sensation and baroreceptor sensitivity. More so, there is reduced oropharyngeal-induced inhibition of AVP release after drinking and the kidneys gradually become unresponsive to even higher levels of circulating AVP, thereby either leading to volume overload or reducing the body's water retention capacity. These defects combine to increase the susceptibility of elderly people to disturbances in water and electrolyte balance, which manifest as dehydration/hypovolemia and hypernatremia, or overhydration and hyponatremia. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.iosrjournals.org/iosr-jdms/papers/Vol18-issue7/Series-4/J1807047180.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
