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Inflammation and endothelial activation in benign prostatic hyperplasia and prostate cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pace, Gianna Massimo, Caterina Di Amicis, Daniela De Vicentini, Carlo Ciancarelli, Maria Giuliana Tozzi |
| Copyright Year | 2011 |
| Abstract | PURPOSE Emerging insights underline a link among chronic inflammation and endothelial activation with benign prostatic hyperplasia (BPH) and prostate cancer (PCa). We aim to investigate whether specific plasma markers of inflammation and endothelial activation allow to discriminate BPH and PCa. MATERIALS AND METHODS Fifteen patients affected by BPH, 15 by PCa and 15 controls, were enrolled. Interleukin-6 (IL-6), CD40 ligand (CD40L), endothelial-selectin (E-selectin), platelet-selectin (P-selectin), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) were measured. RESULTS In systemic blood samples, IL-6 has been found increased in patients affected by BPH (4.25 ± 0. pg/mL) and PCa (5.08 ± 0.24) respect to controls (2.62 ± 0.34; p < 0.05). CD40L was higher in BPH (4.25 ± 0.65 ng/mL; p < 0.05) than in control (2.31 ± 0.20) and PCa group (2.60 ± 0.56). E-selectin, P-selectin and VCAM-1 did not show any significant difference. Higher levels of ICAM-1 were detected in patients with PCa (573.04 ± 52.23) and BPH (564.40 ± 74.67) than in the controls (215.30 ± 11.53 ng/mL; p < 0.05). In local blood samples, IL-6 has been found significantly increased in PCa in comparison with patients with BPH; there was no difference in CD40L, E-selectin, P-selectin, VCAM-1 ed ICAM-1. CONCLUSIONS Changes in inflammation and endothelial activation markers may be not considered to be of value in discriminating BPH and PCa. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.brazjurol.com.br/september_october_2011/Pace_617_622.pdf |
| Alternate Webpage(s) | http://www.scielo.br/pdf/ibju/v37n5/08.pdf |
| PubMed reference number | 22099274v1 |
| Volume Number | 37 |
| Issue Number | 5 |
| Journal | International braz j urol : official journal of the Brazilian Society of Urology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anti-Inflammatory Agents Benign Prostatic Hyperplasia Blood Platelet Disorders Blood Platelets Blood specimen CD40 Ligand Disease E-Selectin Endothelium Inflammation Intercellular adhesion molecule 1 Ligands P-Selectin Patients Prostate Prostatic Diseases Prostatic Neoplasms Selectins Therapeutic procedure Vascular Cell Adhesion Molecule-1 Vascular Cell Adhesion Molecule-1, human negative regulation of leukocyte cell-cell adhesion |
| Content Type | Text |
| Resource Type | Article |
