Assessment of myocardial perfusion by harmonic power Doppler imaging at rest and during adenosine stress: comparison with (99m)Tc-sestamibi SPECT imaging.

Content Provider	Semantic Scholar
Author	Heinle, Sheila K. Noblin, J. E. Goree-Best, P. Mello, Ap Ravad, Guy A. Mull, Stephanie Mammen, Ppa Grayburn, Paul Arthur
Copyright Year	2000
Abstract	BACKGROUND Harmonic power Doppler imaging (HPDI) is a novel technique for assessing myocardial perfusion by contrast echocardiography in humans. The purpose of this study was to compare myocardial perfusion by HPDI with that obtained by (99m)Tc-sestamibi single photon emission computed tomography (SPECT) during rest and pharmacological stress. METHODS AND RESULTS HPDI was performed on 123 patients who were referred for SPECT imaging for known or suspected coronary artery disease. Images were obtained at baseline and during adenosine infusion (0.14 mg. kg(-)(1). min(-)(1)x6 minutes) in 3 apical views. Myocardial perfusion by HPDI was graded for each coronary territory as absent, patchy, or full. The persistence of absent or patchy myocardial perfusion by HPDI between rest and adenosine was interpreted as a fixed defect, whereas any decrease in perfusion grade was interpreted as a reversible defect. Overall concordance between HPDI and SPECT was 83 (81%) of 103 for normal versus abnormal perfusion. Agreement between the 2 methods for each of the 3 coronary territories was 81% (kappa=0.57) for the left anterior descending artery, 76% (kappa=0.52) for the right coronary artery, and 72% (kappa=0.40) for the left circumflex artery. Discrepancies between the 2 techniques were most notable in the circumflex territory, where fixed defects were observed in 33% by HPDI but in only 14% by SPECT (chi(2)=15.8, P=0.0001). CONCLUSIONS This study demonstrates that HPDI can reliably detect myocardial perfusion during pharmacological stress, although there was a significantly higher number of falsely abnormal results in the circumflex territory.
Starting Page	55
Ending Page	60
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1161/01.CIR.102.1.55
PubMed reference number	10880415
Journal	Medline
Volume Number	102
Issue Number	1
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/102/1/55.full.pdf?download=true
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/102/1/55.full.pdf
Journal	Circulation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article