Striking inverse correlation between IgG anti-F(ab')2 and autoantibody production in patients with cold agglutination.

Content Provider	Semantic Scholar
Author	Terness, Peter Kirschfink, Michael Navolan, Dan Dufter, Christoph Kohl, Ingrid Opelz, Gerhard Roelcke, Dieter
Copyright Year	1995
Abstract	Previous experiments showed that the physiologic IgG anti-F(ab')2 antibody suppresses the response of human autoreactive B cells. In the present study, we analyzed the IgG anti-F(ab')2 antibody in 293 patients with cold agglutination (CA). Their average IgG anti-F(ab')2 titer was not much different (211 +/- 8.3) from that of 279 healthy persons (195 +/- 6.7). However, CA patients with high anti-F(ab')2 titers had low CA autoantibody titers and vice versa (P = .0028; rho = -0.175). The stratification of patients according to the auto-antibody's specificity (anti-I, anti-i, anti-Pr) showed an inverse correlation between anti-F(ab')2 and CA in the anti-I group (P = .0057; rho = -0.180). Interestingly, the association was present only in patients whose disease was caused by noninfectious agents (P < .0001; rho = -0.423). The inverse correlation argues for an important role of the IgG anti-F(ab')2 in the regulation of autoantibody production in CA patients.
File Format	PDF HTM / HTML
DOI	10.1016/s0887-7963(05)80097-5
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/85/2/548.full.pdf?sso-checked=true
PubMed reference number	7812010
Alternate Webpage(s)	https://doi.org/10.1016/s0887-7963%2805%2980097-5
Journal	Medline
Volume Number	85
Issue Number	2
Journal	Blood
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article