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High frequency of Mycoplasma pneumoniae among patients with atypical pneumonia in Tehran, Iran.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Arfaatabar, Maryam Aminharati, Farzaneh Azimi, Ghasem Ashtari, Abbas Pourbakhsh, Seyed Ali Masoorian, Ensieh Pourmand, Mohammad Javad |
| Copyright Year | 2018 |
| Abstract | Introduction Mycoplasma pneumoniae is a major cause of atypical community-acquired pneumonia (CAP) with a prevalence range of 15-20% and up to 40% in adults and children, respectively. In Iran, the recorded frequency ranges between 1-6.15%. We aimed to investigate the frequency of M. pneumoniae among patients with atypical pneumonia acquired from the community. Methods Over a period of 5 months between January and June 2017, 520 patients with suspected CAP, who had been to the hospital outpatient clinics of Tehran University, were enrolled in this study. Throat swab specimens were obtained from 110 outpatients who presented with symptoms of atypical pneumonia. M. pneumoniae was identified via culture and biochemical tests, such as fermentation of glucose and arginine, hemolysis, and hemadsorption. For confirmation, PCR was performed to amplify the gene fragment coding for p1 adhesin. Results The major and minor clinical signs of the patients were dyspnea (67.3%) and nausea (15.5%), respectively. Out of 110 specimens, 25 (22.7%) and 29 (26.4%) isolates were identified to be M. pneumoniae via culture and molecular assay, respectively. Comparing the results of the two methods, the PCR showed better sensitivity and rapidity for the detection of M. pneumoniae. There was a high congruence between culture and the PCR assay; kappa level was 'almost perfect' (κ=0.90). Conclusion This is the first report of high frequency of M. pneumoniae in our region. This finding can serve as baseline information for further investigation and confirmation of the potential epidemics of M. pneumoniae pneumonia in our community. |
| Starting Page | 126 |
| Ending Page | 133 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.tums.ac.ir/1397/06/14/Article.pdf-mpourmand-2018-09-05-03-17.pdf |
| PubMed reference number | 30250831v1 |
| Alternate Webpage(s) | https://doi.org/10.18683/germs.2018.1139 |
| DOI | 10.18683/germs.2018.1139 |
| Journal | Germs |
| Volume Number | 8 |
| Issue Number | 3 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acquired Immunodeficiency Syndrome Adhesins, Bacterial Amino Acids Atypical pneumonia Clinic Dyspnea Electron Microscopy Folic Acid Glucose Hemadsorption Hemolysis (disorder) Laboratory Procedures MPZ gene Manuscripts Mycoplasma pneumoniae Nausea Outpatient Clinics, Hospital Outpatients Patients Pneumocystis jiroveci pneumonia Specimen community acquired pneumonia confirmation - ResponseLevel |
| Content Type | Text |
| Resource Type | Article |
