NDLI: MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells.

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MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells.

Content Provider	Semantic Scholar
Author	Gal, Hilah Pandi, Gopal Kanner, A. A. Lithwick-Yanai, Gila Amariglio, Ninette Rechavi, Gideon Givol, David
Copyright Year	2008
Abstract	We examined the microRNA profiles of Glioblastoma stem (CD133+) and non-stem (CD133-) cell populations and found up-regulation of several miRs in the CD133- cells, including miR-451, miR-486, and miR-425, some of which may be involved in regulation of brain differentiation. Transfection of GBM cells with the above miRs inhibited neurosphere formation and transfection with the mature miR-451 dispersed neurospheres, and inhibited GBM cell growth. Furthermore, transfection of miR-451 combined with Imatinib mesylate treatment had a cooperative effect in dispersal of GBM neurospheres. In addition, we identified a target site for SMAD in the promoter region of miR-451 and showed that SMAD3 and 4 activate such a promoter-luciferase construct. Transfection of SMAD in GBM cells inhibited their growth, suggesting that SMAD may drive GBM stem cells to differentiate to CD133- cells through up-regulation of miR-451 and reduces their tumorigenicity. Identification of additional miRs and target genes that regulate GBM stem cells may provide new potential drugs for therapy.
Starting Page	86
Ending Page	90
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.bbrc.2008.08.107
PubMed reference number	18765229
Journal	Medline
Volume Number	376
Issue Number	1
Alternate Webpage(s)	http://www.brainlife.org/abstract/2008/gal_h080831.pdf
Journal	Biochemical and biophysical research communications
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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