Loading...
Please wait, while we are loading the content...
Similar Documents
AIM-1: a mammalian midbody-associated protein required for cytokinesis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Terada, Yasuhiko Tatsuka, Masaaki Suzuki, Fumio Yasuda, Yoshinari Fujita, Shigeru Otsu, Masayuki |
| Copyright Year | 1998 |
| Abstract | Mitosis is a highly coordinated process that assures the fidelity of chromosome segregation. Errors in this process result in aneuploidy which can lead to cell death or oncogenesis. In this paper we describe a putative mammalian protein kinase, AIM-1 (Aurora and Ipl1-like midbody-associated protein), related to Drosophila Aurora and Saccharomyces cerevisiae Ipl1, both of which are required for chromosome segregation. AIM-1 message and protein accumulate at G2/M phase. The protein localizes at the equator of central spindles during late anaphase and at the midbody during telophase and cytokinesis. Overexpression of kinase-inactive AIM-1 disrupts cleavage furrow formation without affecting nuclear division. Furthermore, cytokinesis frequently fails, resulting in cell polyploidy and subsequent cell death. These results strongly suggest that AIM-1 is required for proper progression of cytokinesis in mammalian cells. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://emboj.embopress.org/content/embojnl/17/3/667.full.pdf |
| PubMed reference number | 9450992v1 |
| Volume Number | 17 |
| Issue Number | 3 |
| Journal | The EMBO journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | AURKB protein, human Aneuploidy Cell Death Chromosome Segregation Cytokinesis of the fertilized ovum Mammals Mitosis Mitotic Telophase Polyploidy Protein Kinases Spindle cell surface furrow cleavage furrow formation midbody nuclear division |
| Content Type | Text |
| Resource Type | Article |
