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What are the pros and cons of the use of host-targeted agents against hepatitis C?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pawlotsky, Jean-Michel |
| Copyright Year | 2014 |
| Abstract | Abstract Hepatitis C virus (HCV) therapy is living a revolution. Host-targeted agents (HTAs) block HCV production by interacting with host cell components. Because they target conserved host proteins, not variable viral proteins, HTAs have the potential for pangenotypic antiviral activity and a high barrier to resistance. Only two HTAs have reached clinical development, including specific inhibitors of cyclophilin A peptidyl-prolyl cis/trans isomerase activity and antagonists of microRNA-122. Cyclophilin inhibitors have proven to be relatively well tolerated and can be confidently used as backbones of all-oral, interferon-free regimens. In addition, HTAs such as cyclophilin inhibitors offer opportunities for “panviral” approaches when they target mechanisms common to viruses of the same or different families. This article forms part of a symposium in Antiviral Research on “Hepatitis C: next steps toward global eradication.” |
| Starting Page | 22 |
| Ending Page | 25 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 24583032 |
| Journal | Medline |
| Volume Number | 105 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0166354214000515 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0166354214000515 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.antiviral.2014.02.008 |
| Journal | Antiviral Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
