NDLI: stem and progenitor cells and synergises with tyrosine kinase inhibitors BMS-214662 potently induces apoptosis of chronic myeloid leukemia

Please wait, while we are loading the content...

stem and progenitor cells and synergises with tyrosine kinase inhibitors BMS-214662 potently induces apoptosis of chronic myeloid leukemia

Content Provider	Semantic Scholar
Author	Copland, Mhairi Pellicano, Francesca Richmond, Linda Allan, Elaine K. Hamilton, Ashley Lee, Francis Young-In Weinmann, Roberto Holyoake, Tessa L.
Copyright Year	2007
Abstract	Chronic myeloid leukemia (CML), a hematopoietic stem cell disorder, cannot be eradicated by conventional chemotherapy or the tyrosine kinase inhibitor (TKI) imatinib mesylate (IM). To target CML stem/progenitor cells we investigated BMS-214662, a cytotoxic farnesyltransferase inhibitor, previously reported to kill non-proliferating tumor cells. IM or dasatinib alone reversibly arrested proliferation of CML stem/progenitor cells without inducing apoptosis. In contrast, BMS-214662, alone or in combination with IM or dasatinib, potently induced apoptosis of both proliferating and quiescent CML stem/progenitor cells with <1% recovery of Philadelphia positive LTC-IC. Normal stem/progenitor cells were relatively spared by BMS-214662, suggesting selectivity for leukemic stem/progenitor cells. The ability to induce selective apoptosis of leukemic stem/progenitor cells was unique to BMS214662 and not seen with a structurally similar agent BMS-225975. BMS214662 was cytotoxic against CML blast crisis stem/progenitor cells, particularly in combination with a TKI and equally effective in cell lines harbouring wild-type versus mutant BCR-ABL, including the T315I mutation. This is the first report of an agent with activity in resistant and blast crisis CML that selectively kills CML stem/progenitor cells through apoptosis and offers potential for eradication of chronic phase CML. only. For personal use at PENN STATE UNIVERSITY on February 20, 2013. bloodjournal.hematologylibrary.org From
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://bloodjournal.hematologylibrary.org/content/early/2007/12/21/blood-2007-09-112573.full.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in