NDLI: Relative Expression of 1,25-Dihydroxyvitamin D3 Receptor, Vitamin D 1α-Hydroxylase, Vitamin D 24-Hydroxylase, and Vitamin D 25-Hydroxylase in Endometriosis and Gynecologic Cancers

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Relative Expression of 1,25-Dihydroxyvitamin D3 Receptor, Vitamin D 1α-Hydroxylase, Vitamin D 24-Hydroxylase, and Vitamin D 25-Hydroxylase in Endometriosis and Gynecologic Cancers

Content Provider	Semantic Scholar
Author	Agic, Admir Altgassen, Christopher Noack, Frank Wolfler, Monika M. Diedrich, Klaus M. Friedrich, Michael Taylor, Robert N. Hornung, Daniela
Copyright Year	2007
Abstract	The authors demonstrate expression of the vitamin D receptor (VDR) and its hydroxylases in the endometrium and ovaries of women with and without endometriosis and endometrial or ovarian cancer. Immunohistochemistry showed strong staining of the VDR in endometriosis and endometrial cancer, with the most intense staining in epithelial cells. The VDR mRNA was significantly increased in patients with endometrial and ovarian cancer compared to the control group. There was a significantly higher 1α-hydroxylase expression in the endometrium of patients with endometriosis compared to healthy controls. The observed differences in VDR and 1α -hydroxylase mRNA levels were maintained at the protein level. The authors found no differences in 25-OH vitamin D levels between the serum of patients with endometriosis (25.7 ± 2.1 ng/mL, n = 46) and healthy controls (22.6 ± 2.0 ng/mL, n = 33, P = .31). They hypothesize that vitamin D might influence the local activity of immune cells and cytokines thought to play important pathogenic roles in the development and maintenance of endometriosis.
Starting Page	486
Ending Page	497
Page Count	12
File Format	PDF HTM / HTML
PubMed reference number	17913968
Journal	Medline
Volume Number	14
Alternate Webpage(s)	https://www.deutsche-digitale-bibliothek.de/binary/QVEAZQF55CFIKT326Q5RVGDTBSCMDEDI/full/1.pdf
Alternate Webpage(s)	https://doi.org/10.1177/1933719107304565
Journal	Reproductive Sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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