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Where does parkinson disease pathology begin in the brain?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tredici, Kelly Del Rüb, Udo Vos, Rob De Bohl, Jürgen R. E. Braak, Heiko |
| Copyright Year | 2002 |
| Abstract | The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative study of 30 autopsy cases with incidental Lewy body pathology indicate that PD in the brain commences with the formation of the very first immunoreactive Lewy neurites and Lewy bodies in non-catecholaminergic neurons of the dorsal glossopharyngeus-vagus complex, in projection neurons of the intermediate reticular zone, and in specific nerve cell types of the gain setting system (coeruleus-subcoeruleus complex, caudal raphe nuclei, gigantocellular reticular nucleus), olfactory bulb, olfactory tract, and/or anterior olfactory nucleus in the absence of nigral involvement. The topographical parcellation of the nuclear grays described here is based upon known architectonic analyses of the human brainstem and takes into consideration the pigmentation properties of a few highly susceptible nerve cell types involved in PD. In this sample and in all 58 age- and gender-matched controls, Lewy bodies and Lewy neurites do not occur in any of the known prosencephalic predilection sites (i.e. hippocampal formation, temporal mesocortex, proneocortical cingulate areas, amygdala, basal nucleus of Meynert, interstitial nucleus of the diagonal band of Broca, hypothalamic tuberomamillary nucleus). |
| Starting Page | 579 |
| Ending Page | 579 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jnen.oxfordjournals.org/content/jnen/61/5/413.full.pdf |
| PubMed reference number | 12030260v1 |
| Volume Number | 61 |
| Issue Number | 5 |
| Journal | Journal of neuropathology and experimental neurology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amygdaloid structure Basal Nucleus of Meynert Brain Stem Caudal Cell Nucleus Gyrus Cinguli Hippocampus (Brain) Lewy Bodies Lewy Body Disease Neurites Neurons Olfactory tract Parkinson Disease Parkinsonian Disorders Pigmentation Structure of olfactory bulb Substantia nigra structure Vagus nerve structure anterior olfactory nucleus cell type raphe nuclei |
| Content Type | Text |
| Resource Type | Article |
