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Manifestaciones hepatobiliares en pacientes con enfermedad inflamatoria crónica intestinal
| Content Provider | Semantic Scholar |
|---|---|
| Author | García, Olga Marina Hano Abizaid, Yirian Tatiana Ojeda Fabián, Licet González Rodríguez, Yoan Antonio Sánchez |
| Copyright Year | 2012 |
| Abstract | Es frecuente que en pacientes con enfermedad inflamatoria intestinal se observen cambios analiticos o clinicos que indican la existencia de una enfermedad hepatobiliar. La frecuencia de estos hallazgos oscila entre 11-49 porciento en colitis ulcerosa y entre 15-30 porciento en enfermedad de Crohn. En algunos casos, estas alteraciones se observan desde el primer momento en que se estudia a los pacientes, otras surgen en el curso de la enfermedad. Se realizo un estudio descriptivo observacional retrospectivo donde se incluyo 180 pacientes con enfermedad inflamatoria intestinal, que se atienden en el Instituto de Gastroenterologia, de ellos con manifestaciones hepatobiliares, 17 pacientes (9,4 porciento), 12 colitis ulcerosa y 5 Crohn. Las variables estudiadas fueron: sexo, edad, anos de evolucion segun tipo de enfermedad inflamatoria, tipo de manifestacion hepatobiliar, sintomas clinicos, estudio de enzimas hepaticas y hallazgos ultrasonograficos. Se concluyo que existe predominio de pacientes con colitis ulcerosa. Predomino el sexo femenino en la colitis ulcerosa; el Crohn no tuvo variaciones significativas. La edad estuvo comprendida entre 30 y 49 anos. La manifestacion hepatobiliar mas frecuente en el Crohn fue la hepatopatia de etiologia no filiada y en la colitis ulcerosa la colangitis esclerosante primaria. El sintoma clinico que predomino en ambos grupos fue la astenia, y en la colitis ulcerosa tambien predomino el prurito e ictero. Con respecto a las enzimas bioquimicas predomino la hipertransaminasemia, y por ultrasonido el aspecto granular y aumento de la ecogenicidad hepatica It is common for patients with inflammatory bowel disease to present analytical or clinical changes pointing to the presence of hepatobiliary disease. The frequency of such findings ranges between 11-49 percent in ulcerous colitis and between 15-30 percent in Crohn's disease. In some cases, the alterations are found when the patient is first examined, while in others they emerge during the course of the disease. An observational retrospective descriptive study was conducted of 180 patients with inflammatory bowel disease cared for at the Institute of Gastroenterology. Hepatobiliary manifestations were found in 17 patients (9.4 percent): 12 with ulcerous colitis and 5 with Crohn's disease. The variables studied were sex, age, years of evolution by type of inflammatory disease, type of hepatobiliary manifestation, clinical symptoms, study of hepatic enzymes and ultrasonographic findings. There was a predominance of patients with ulcerous colitis. Female sex prevailed in ulcerous colitis. No significant differences were found in Crohn's disease. Age ranged between 30-49. The most common hepatobiliary manifestations were liver disease of unknown etiology in Crohn's disease and primary sclerosing cholangitis in ulcerous colitis. The prevailing clinical symptom in both groups was asthenia. Pruritus and jaundice were also predominant in ulcerous colitis. With respect to biochemical enzymes, there was a predominance of hypertransaminasemia. Ultrasonographically, a granular aspect and increased hepatic echogenicity were the prevailing features |
| Starting Page | 490 |
| Ending Page | 500 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Volume Number | 31 |
| Alternate Webpage(s) | http://www.medigraphic.com/pdfs/revcubinvbio/cib-2012/cib124i.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
