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Plasticity in the projection from the anterior thalamic nuclei to the anterior cingulate cortex in the rat in vivo: paired-pulse facilitation, long-term potentiation and short-term depression
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gemmell, Colin Mara, Shane M. O’ |
| Copyright Year | 2002 |
| Abstract | Several neurophysiological and computational theories of the rodent navigational system suggest that the differing cortices of the frontal lobe and thalamus share information and therefore undergo changes in synaptic strength. We examine here for the first time three forms of synaptic plasticity in the projection from the anterior thalamic nuclei to the anterior cingulate cortex: we demonstrate that this projection is capable of expressing paired-pulse facilitation, long-term potentiation, and short-term depression. Furthermore, input/output curves show that field excitatory post-synaptic potential amplitude increased at all stimulus intensities following high-frequency stimulation. These findings add important information to our understanding of synaptic plasticity in this important pathway, which has been widely hypothesized to play important roles in memory and spatial representation in the rodent. |
| Starting Page | 401 |
| Ending Page | 406 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0306-4522(01)00554-1 |
| PubMed reference number | 11823054 |
| Journal | Medline |
| Volume Number | 109 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0306452201005541 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0306452201005541?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0306-4522%2801%2900554-1 |
| Journal | Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
