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Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rottman, Jeffrey N. Bracy, Deanna P. Malabanan, Carlo M. Clanton, Jeff Wasserman, David H. |
| Copyright Year | 2002 |
| Abstract | Isotopic techniques were used to test the hypothesis that exercise and nitric oxide synthase (NOS) inhibition have distinct effects on tissue-specific fatty acid and glucose uptakes in a conscious, chronically catheterized mouse model. Uptakes were measured using the radioactive tracers (125)I-labeled beta-methyl-p-iodophenylpentadecanoic acid (BMIPP) and deoxy-[2-(3)H]glucose (DG) during treadmill exercise with and without inhibition of NOS. [(125)I]BMIPP uptake at rest differed substantially among tissues with the highest levels in heart. With exercise, [(125)I]BMIPP uptake increased in both heart and skeletal muscles. In sedentary mice, NOS inhibition induced by nitro-L-arginine methyl ester (L-NAME) feeding increased heart and soleus [(125)I]BMIPP uptake. In contrast, exercise, but not L-NAME feeding, resulted in increased heart and skeletal muscle [2-(3)H]DG uptake. Significant interactions were not observed in the effects of combined exercise and L-NAME feeding on [(125)I]BMIPP and [2-(3)H]DG uptakes. In the conscious mouse, exercise and NOS inhibition produce distinct patterns of tissue-specific fatty acid and glucose uptake; NOS is not required for important components of exercise-associated metabolic signaling, or other mechanisms compensate for the absence of this regulatory mechanism. |
| File Format | PDF HTM / HTML |
| DOI | 10.1152/ajpendo.00545.2001 |
| PubMed reference number | 12067851 |
| Journal | Medline |
| Volume Number | 283 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://ajpendo.physiology.org/content/ajpendo/283/1/E116.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1152/ajpendo.00545.2001 |
| Journal | American journal of physiology. Endocrinology and metabolism |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
