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Biocompatibility and osteogenic properties of porous tantalum
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Qian Zhang, Hui Li, Qijia Ye, Lei Gan, Hongquan Liu, Yingjie Wang, Hui Wang, Zhiqiang |
| Copyright Year | 2015 |
| Abstract | Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and proliferation were investigated using optical microscopy and SEM. In addition, porous tantalum rods were implanted in rabbits, and osteogenesis was observed using laser scanning confocal microscopy and hard tissue slice examination. The osteoblasts were observed to proliferate over time and adhere to the tantalum surface and pore walls, exhibiting a variety of shapes and intercellular connections. The porous tantalum rod connected tightly with the host bone. At weeks 2 and 4 following implantation, new bone and small blood vessels were observed at the tantalum-host bone interface and pores. At week 10 after the porous tantalum implantation, new bone tissue was observed at the tantalum-host bone interface and pores. By week 12, the tantalum-host bone interface and pores were covered with new bone tissue and the bone trabeculae had matured and connected directly with the materials. Therefore, the results of the present study indicate that porous tantalum is non-toxic, biocompatible and a promising material for use in bone tissue engineering applications. |
| Starting Page | 780 |
| Ending Page | 786 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/etm/9/3/780/download |
| PubMed reference number | 25667628 |
| Volume Number | 9 |
| Journal | Experimental and therapeutic medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Blood Vessel Bone Tissue Bone Trabeculae Cellular Morphology Exhibits as Topic Implants Microscopy, Confocal Microscopy, Confocal, Laser Scanning Osteoblasts Rod Photoreceptors Scanning Electron Microscopy Tantalum Tissue Engineering Walls of a building biocompatibility |
| Content Type | Text |
| Resource Type | Article |
