NDLI: Water does not flow across the tight junctions of MDCK cell epithelium.

Content Provider	Semantic Scholar
Author	Kovbasnjuk, Olga Weinstein, Alan M. Spring, Kenneth R.
Copyright Year	1998
Abstract	Although it has been known for decades that the tight junctions of fluid-transporting epithelia are leaky to ions, it has not been possible to determine directly whether significant transjunctional water movement also occurs. An optical microscopic technique was developed for the direct visualization of the flow velocity profiles within the lateral intercellular spaces of a fluid-absorptive, cultured renal epithelium (MDCK) and used to determine the velocity of the fluid flow across the tight junction. The flow velocity within the lateral intercellular spaces fell to near zero adjacent to the tight junction, showing that significant transjunctional flow did not occur, even when transepithelial fluid movement was augmented by imposition of osmotic gradients.
File Format	PDF HTM / HTML
PubMed reference number	9601000
Journal	Medline
Volume Number	95
Issue Number	11
Alternate Webpage(s)	http://www.pnas.org/content/95/11/6526.full.pdf
Alternate Webpage(s)	https://doi.org/10.1073/pnas.95.11.6526
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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