NDLI: Protective Effect of Apigenin against Ethinylestrad iol induced Toxic Effects in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ)Bg 9

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Protective Effect of Apigenin against Ethinylestrad iol induced Toxic Effects in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ)Bg 9

Content Provider	Semantic Scholar
Author	Siddique, Yasir Hasan Ara, G. Miguel Jyoti, Smita Naz, Falaq Afzal, Mohammad
Copyright Year	2011
Abstract	Summary All living organisms under stressful condition resp ond by synthesizing heat shock proteins (HSPs). In recent years, hsp70 has been considered to be one of the candidate gen es for predicting the cytotoxicity against environmental c hemicals. The effect of apigenin was studied against the toxic effects induced by ethiny lestradiol in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg 9 using hsp70 expression and dye exclusion test as a parameter. The effect of 0.1, 0.50 and 1.0 μl/ml of apigenin was studied against the toxic effects induced by 0.50 and 1.0 μl/ml of ethinylestradiol in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg 9 using hsp70 expression and dye exclusion test as a parameter. The selected dos es of apigenin for the estimation of hsp70 expression in the third instar larvae (i.e. 0.1, 0. 5 and 1.0 μl/ml) were not toxic though reduced significantly, the expression of hsp70 and tissue damage induced by 0.5 and 1.0 μl/ml of ethinylestradiol. The results demonstrates the protective role of apigenin against the toxicity of ethinylestradiol in the third instar la rvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg 9 and also promotes the use of alternative to higher laboratory animals such as mice/rats for the initial screening of the chemi cal agents for their possible toxic or protective effects.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://pharmacologyonline.silae.it/files/archives/2011/vol3/071.siddique.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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