NDLI: Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

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Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

Content Provider	Semantic Scholar
Author	Campbell, Kenneth S. Ogris, Egon Burke, Bryan E. Su, Weicheng Auger, Kurt R. Druker, Brian J. Schaffhausen, Brian S. Roberts, Thomas M. Pallas, David C.
Copyright Year	1994
Abstract	Polyomavirus middle tumor antigen (MT) transforms a large number of cell types by binding to and modulating the activities of cellular proteins. Previous genetic analysis defined in MT an independent motif, NPTY (Asn-Pro-Thr-Tyr), required for transformation. This report demonstrates that NPTY is required for interaction between MT and SHC protein, a Src homology 2 (SH2)-containing protooncogene product implicated in activating Ras via association with GRB2 protein. SHC is phosphorylated on tyrosine and associates with GRB2 in MT-transformed cells. These effects require an intact NPTY motif in MT. SHC immunoprecipitates from MT-transformed cells possess kinase activity that phosphorylates not only SHC and MT but also the 85-kDa subunit of phosphatidylinositol 3-kinase. This result suggests that a complex exists that contains, at a minimum, MT, Src family tyrosine kinases, phosphatidylinositol 3-kinase, and SHC.
Starting Page	1138
Ending Page	1138
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/91/14/6344.full.pdf
PubMed reference number	8022784v1
Volume Number	91
Issue Number	14
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	1-Phosphatidylinositol 3-Kinase Asparagine Homologous Gene MONOPHENOL MONOOXYGENASE Polyomavirus Protein Domain Proto-Oncogenes SHC1 protein, human Threonine Tumor Antigens Tyrosine kinase activity v-src protein
Content Type	Text
Resource Type	Article

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