NDLI: The genetics of circadian rhythms, sleep and health

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The genetics of circadian rhythms, sleep and health

Content Provider	Semantic Scholar
Author	Jagannath, Aarti Taylor, Lewis Wakaf, Zeinab Sridhar R. Vasudevan Foster, Russell G.
Copyright Year	2017
Abstract	Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular clocks, which serve to coordinate internal time with the external world. The circadian system is a master regulator of nearly all physiology and its disruption has major consequences on health. Sleep and circadian rhythm disruption (SCRD) is a ubiquitous feature in today's 24/7 society, and studies on shift-workers have shown that SCRD can lead not only to cognitive impairment, but also metabolic syndrome and psychiatric illness including depression (1,2). Mouse models of clock mutants recapitulate these deficits, implicating mechanistic and causal links between SCRD and disease pathophysiology (3-5). Importantly, treating clock disruption reverses and attenuates these adverse health states in animal models (6,7), thus establishing the circadian system as a novel therapeutic target. Significantly, circadian and clock-controlled gene mutations have recently been identified by Genome-Wide Association Studies (GWAS) in the aetiology of sleep, mental health and metabolic disorders. This review will focus upon the genetics of circadian rhythms in sleep and health.
Starting Page	R128
Ending Page	R138
Page Count	1
File Format	PDF HTM / HTML
PubMed reference number	28977444v1
Alternate Webpage(s)	https://doi.org/10.1093/hmg/ddx240
DOI	10.1093/hmg/ddx240
Journal	Human molecular genetics
Volume Number	26
Language	English
Access Restriction	Open
Subject Keyword	Animal Model Circadian Rhythms Cognition Disorders Depressive disorder Genome-Wide Association Study Mental disorders Metabolic Diseases Metabolic Syndrome X Sleep Disorders, Circadian Rhythm mental health mutant physiological aspects
Content Type	Text
Resource Type	Article

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