NDLI: Graft-vs.-host-associated immune suppression is activated by recognition of allogeneic murine I-A antigens

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Graft-vs.-host-associated immune suppression is activated by recognition of allogeneic murine I-A antigens

Content Provider	Semantic Scholar
Author	Shearer, G. M. Levy, Robert H.
Copyright Year	1983
Abstract	Several combinations of F1 hybrid mice were injected intravenously with parental spleen cells to determine the minimal H-2 differences between F1 and parent that are necessary to induce graft-vs.-host-associated immune suppression (GVH-associated suppression). 7-14 d after injection, the spleens of the F1 mice were tested for cytotoxic T lymphocyte potential by in vitro sensitization against trinitrophenyl-self and H-2 alloantigens. The results indicate that parental T lymphocytes must recognize I-A allogeneic determinants of the F1 recipient in order to induce suppression. Recognition of K or D alone or D with I region products other than I-A did not induce suppression. The recognition of I region without K and/or D and even the I-A difference between C57BL/6 and the B6.Cbm12 mutation resulted in immune suppression that was as potent as that resulting from the recognition of K, D, and I together. The possible significance of this function for I-A antigens is discussed with respect to three clinical examples of immune suppression for which this phenomenon may be relevant.
Starting Page	936
Ending Page	946
Page Count	11
File Format	PDF HTM / HTML
PubMed reference number	6403650
Volume Number	157
Journal	The Journal of experimental medicine
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/93/5b/je1573936.PMC2186963.pdf
Alternate Webpage(s)	http://jem.rupress.org/content/jem/157/3/936.full.pdf
Language	English
Access Restriction	Open
Subject Keyword	C57BL/6 Mouse Cell-Mediated Cytolysis Cytotoxic T-Lymphocytes Graft-vs-Host Disease Helper-Inducer T-Lymphocyte In Vitro [Publication Type] Mutation Sensitization (observable entity) Spleen Transplanted tissue childhood lymphocyte depletion Hodgkin's lymphoma
Content Type	Text
Resource Type	Article

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