Loading...
Please wait, while we are loading the content...
Similar Documents
EFEK KOMBINASI KLOROKUIN DAN N-ACETYL CYSTEINE TERHADAP JUMLAH TROMBOSIT MENCIT GALUR BALB/C YANG DIINFEKSI Plasmodium berghei (THE EFFECT OF COMBINATION OF CHLOROQUINE AND N-ACETYL CYSTEINE ON AMOUNT OF PLATELETS IN BALB/C MICE INFECTED BY Plasmodium berghei)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mulyastuti, Yuanita Widijanti, Anik Ali, Mulyohadi Iskandar, Agustin Fitri, Loeki E. Malang, Saiful Anwar |
| Copyright Year | 2012 |
| Abstract | Malaria is the most important of the parasitic diseases of humans. In Indonesia, about more than 70 million people live in area which is endemic to malaria, about 15 million new case of malaria occurred every year. In malaria immune response forms free radical which assist to eliminate the cause of disease but also destroys endothelial cells at various organ. This oxidative damage plays an important role in the development of malarial thrombocytopenia. The aim of this research was to investigate the effect of Choroquine combine with N-Acetyl cysteine on the degree of parasitemia and platelets amount during malaria infection. Combination of Chloroquine and N-Acetyl cysteine have been tested by using experimental research method in male Balb/c mice which was infected by Plasmodium berghei. Measurement of the degree of parasitemia was done everyday and the amount of the platelet as one of the nonspecific cellular immunity parameter at malaria was calculated once in three days. Treatment group were divided to eight groups, group of chloroquine(0,05 mg/gr), group of N-Acetyl cysteine with dose 0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr and also combination group of chloroquine and N-Acetyl cysteine with constant dose of chloroquine(0,05 mg/gr) and various dose of N-Acetyl cysteine(0,25 mg/gr, 0,5 mg/gr, and 1 mg/gr). One group consisted of infected mice without treatment as control group. Significant degradation of parasitemia was noted in combination group of chloroquine and N-Acetyl cysteine during the infection of malaria (p < 0,05). Amount of platelet at combination group of chloroquine and N-Acetyl cysteine was higher than control (p > 0,05). The conclusion this research is combination of chloroquine and N-Acetyl cysteine can degrade the degree of parasitemia, but not yet proven degradation of platelet amount during malaria infection. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jkb.ub.ac.id/index.php/jkb/article/download/238/230 |
| Alternate Webpage(s) | https://jkb.ub.ac.id/index.php/jkb/article/download/238/230 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
