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A drug delivery system based on switchable photo-controlled p-coumaric acid derivatives anchored on mesoporous silica.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Beňová, Eva Zeleňák, Vladimír Halamová, Dáša Almáši, Miroslav Petruľová, Veronika Psotka, Miroslav Zeleňáková, Adriána Bačkor, Martin Hornebecq, Virginie |
| Copyright Year | 2017 |
| Abstract | A stimuli-responsive drug delivery system consisting of mesoporous silica with its surface modified by p-coumaric acid derivatives (CA) as photo-switchable ligands was studied for the delivery of the non-steroidal anti-inflammatory drug (NSAID) naproxen. For this purpose, MCM-41 mesoporous silica material was prepared and post-synthetically modified by the grafting of a triethoxysilyl derivative of p-coumaric acid, which undergoes a reversible photo-dimerization under UV irradiation and creates the "valves" on the surface of silica allowing targeted opening/closing of the pores. Naproxen was encapsulated into grafted MCM-41 and drug release studies were performed in two different media, in a simulated gastric fluid (pH = 2) and in a simulated body fluid (pH = 7.4). Differences in drug release were observed after irradiation of the material using UV light at λ = 365 nm (closed pore configuration) and UV light at λ = 254 nm (opened pore configuration). |
| Starting Page | 817 |
| Ending Page | 825 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C6TB02040B |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c6/tb/c6tb02040b/c6tb02040b1.pdf |
| PubMed reference number | 32263850 |
| Alternate Webpage(s) | https://doi.org/10.1039/C6TB02040B |
| Journal | Medline |
| Volume Number | 5 |
| Issue Number | 4 |
| Journal | Journal of materials chemistry. B |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
