NDLI: Epigallocatechin-3-gallate increases the formation of mineralized bone nodules by human osteoblast-like cells.

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Epigallocatechin-3-gallate increases the formation of mineralized bone nodules by human osteoblast-like cells.

Content Provider	Semantic Scholar
Author	Vali, Bahareh Rao, Leticia Gomez El-Sohemy, Ahmed
Copyright Year	2007
Abstract	Consumption of green tea, a rich source of epigallocatechin-3-gallate (EGCG), is associated with increased bone mineral density. However, the direct effects of this flavonoid on bone mineralization are not known. The present study demonstrates the effects of EGCG on the formation of mineralized bone nodules by SaOS-2 human osteoblast (HOB)-like cells. EGCG at concentrations of 1-5 microM caused a dose-dependent increase in the number and area of mineralized bone nodules as assessed by both von Kossa and alizarin red staining. EGCG also increased alkaline phosphatase activity, an early marker of osteoblastic differentiation. After 48 h of treatment, EGCG decreased protein levels of Runx2, a transcription factor that regulates osteoblast maturation by inhibiting late-stage differentiation. The observed effects of EGCG on bone formation by HOB-like cells suggest that EGCG may have beneficial effects on bone health.
Starting Page	15
Ending Page	23
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://tspace.library.utoronto.ca/bitstream/1807/17911/1/Epigallocatechin-3-gallate%20increases%20the%20formation%20of%20mineralized%20bone%20nodules%20by%20human%20osteoblast-like%20cells.pdf
PubMed reference number	16963251v1
Volume Number	18
Issue Number	5
Journal	The Journal of nutritional biochemistry
Language	English
Access Restriction	Open
Subject Keyword	Alkaline Phosphatase Biologic Development Bone Mineralization Bone Tissue Flavonoids Inhibition Osteoblasts Osteogenesis Physiologic calcification Plant Extracts Staining method TRANSCRIPTION FACTOR alizarin epigallocatechin gallate osteoblast development
Content Type	Text
Resource Type	Article

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