NDLI: Formulation and Evaluation of Valsrtan Orodispersible Tablets Using Directly Compressible Co-Processed Excipient of Jujube Ziziphus jujuba Gum

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Formulation and Evaluation of Valsrtan Orodispersible Tablets Using Directly Compressible Co-Processed Excipient of Jujube Ziziphus jujuba Gum

Content Provider	Semantic Scholar
Author	Kumari, Surya S. Panda, Subhranshu
Copyright Year	2019
Abstract	The aim of the present research work is to develop fast dissolving tablets of Valsartan applying novel directly compressible (DC) co-processed excipient which improves the functionality and masking the undesirable properties of the drug without any chemical modification. For the development of co-process excipient, synthetic superdisintegrants like crospovidone, sodium starch Glycolate (SSG) and Croscarmellose sodium(CCS) were processed with natural disintegrates Jujube Ziziphus jujuba gum in varying ratios 1:1 to 1:4. Co-processed excipient prepared from polymers ratio of 1:1 and 1:2 have shown good Physico-chemical properties, pre compression parameters like angle of repose, bulk density, true density, compressibility index. The post compression parameters have shown acceptable and within the pharmacopeia limit. In-vitro drug release for all the formulationsF1 to F12 were found in between 95 to 97% and were satisfactory. The optimized formulation F2, Jujuba gum 4% with 2% of SSG, the drug release was found to be is 97% within 2min. Developed optimized formulations were kept for stability study for one month as per ICH guidelines and found to be stable. The study indicates that use of co-processed excipient has an added advantage over individual polymers and can be used in Orodispersible tablet formulations irrespective of drug type. Ch. Surya Kumari, Subhranshu Panda,
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ijppr.humanjournals.com/wp-content/uploads/2019/12/7.Ch_.-Surya-Kumari-Subhranshu-Panda-S.Sureshbabu-G.Durgarao-K.Chinnababu-K.Venketeswerarao..pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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