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Synthesis of RAFT polymers as bivalent inhibitors of cholera toxin
| Content Provider | Semantic Scholar |
|---|---|
| Author | Leaver, David J. Hughes, Andrew B. Dawson, Raymond Murray Postma, Almar Malic, Nino Polyzos, Anastasios |
| Copyright Year | 2014 |
| Abstract | We report a new strategy to develop low molecular weight (18–28 kDa) poly(N-acryloylmorpholine) (PNAM) polymers as bivalent inhibitors of cholera toxin (CT) using Reversible Addition–Fragmentation chain Transfer (RAFT) technology. The inhibitory activity of the galacto-conjugated polymers was examined (ELISA) and the series displayed moderate inhibitory activity (millimolar IC50). |
| Starting Page | 14868 |
| Ending Page | 14871 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C3RA47500J |
| Volume Number | 4 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ra/c3/c3ra47500j/c3ra47500j1.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |