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The effect of red-fleshed pitaya ( ) on heat Hylocereus polyrhizus shock protein 70 and cortisol expression in strenuous exercise
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zulaini |
| Copyright Year | 2019 |
| Abstract | Oxidative stress from exercise can contribute to damaging Background: cells, increasing heat shock protein 70 (HSP70) and suppressing the immune system in the body. This research aimed to determine the antioxidant potential of red-fleshed pitaya extract on HSP70 and cortisol expression in rats which were subjected to strenuous exercise. The subjects of this research were 32 Sprague Dawley male Methods: rats, aged 3 months, with an average weight of 200 g. Red-fleshed pitaya extract was obtained from methanol extraction process; a maceration technique was performed and the extract was concentrated using an air-drying method. Rats were randomly divided into four groups. Group 1 were subjected to strenuous exercise and treated with distilled water only; while Groups 2, 3 and 4 were subjected to strenuous exercise and treated with 100 mg/kg body weight, 200 mg/kg body weight and 300 mg/kg body weight of red-fleshed pitaya extract, respectively. Strenuous exercises in rats was performed by intense swimming of 20 min/day, 3 days a week for 3 weeks. HSP70 expression and cortisol were measured with Enzyme-Linked Immune Sorbent Assay (ELISA) method. There was a significant reduction of HSP70 (p=0.000) and cortisol Results: expression (p=0.000) between the groups. Also, there was a significant difference in the average decreasing of HSP70 expression between group 4 and either groups 1 or 2 (p=0.000). However, a significant difference between groups 4 and 3 was not observed (p=0.813). Lastly, a significant difference was found in the average decrease of cortisol expression between groups 4 and 1 (p=0.000), 2 (p=0.000), and 3 (p=0.000) respectively. Red-fleshed pitaya is potential to be utilized as antioxidant to Conclusion: decrease the HSP70 and cortisol expression. |
| File Format | PDF HTM / HTML |
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| Alternate Webpage(s) | https://f1000researchdata.s3.amazonaws.com/manuscripts/19175/af03b065-3fba-4901-b162-6d56ef544f4c_17533_-_novita_harahap.pdf?doi=10.12688/f1000research.17533.1&numberOfBrowsableCollections=19&numberOfBrowsableGateways=22&numberOfBrowsableInstitutionalCollections=5 |
| Alternate Webpage(s) | https://f1000researchdata.s3.amazonaws.com/manuscripts/19175/111fabae-99b4-4884-a0de-d08f1343a93a_17533_-_novita_harahap.pdf?doi=10.12688/f1000research.17533.1&numberOfBrowsableCollections=15&numberOfBrowsableGateways=24 |
| Alternate Webpage(s) | https://f1000researchdata.s3.amazonaws.com/manuscripts/19175/c613ec91-ce40-4073-9027-69e8023d1307_17533_-_novita_harahap.pdf?doi=10.12688/f1000research.17533.1&numberOfBrowsableCollections=18&numberOfBrowsableGateways=22&numberOfBrowsableInstitutionalCollections=5 |
| Alternate Webpage(s) | https://f1000researchdata.s3.amazonaws.com/manuscripts/19175/eceb372b-20c1-43c5-a444-4a45d21c16fc_17533_-_novita_harahap.pdf?doi=10.12688/f1000research.17533.1&numberOfBrowsableCollections=20&numberOfBrowsableGateways=23&numberOfBrowsableInstitutionalCollections=5 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
