NDLI: Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats.

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Hyperglycemia enlarges infarct size in cerebrovascular occlusion in cats.

Content Provider	Semantic Scholar
Author	Courten-Myers, Gabrielle M. De Myers, Ronald E. Schoolfield, L.
Copyright Year	1988
Abstract	We investigated the influence of serum glucose concentration on infarct size following middle cerebral artery occlusion in cats. These animals were deprived of food for 48 hours and infused with 1) saline for 1 hour before and 8 hours after occlusion (n = 8), 2) 10% glucose solution for 1 hour before and 6 hours after occlusion and saline for 2 additional hours (n = 8), or 3) 10% glucose for 1 hour before and saline for 8 hours after occlusion (n = 5). Nineteen cats killed after 2 weeks' survival were subjected to morphometric infarct size determinations. Eight normoglycemic and 11 hyperglycemic cats exhibited infarcts affecting 10.2 +/- 3.4% and 29.5 +/- 6.5% (mean +/- SEM) of their middle cerebral artery territories, respectively (p less than 0.02). Cats of the two hyperglycemic groups showed similarly sized infarcts. However, two of eight (25%) of cats with preocclusion and postocclusion hyperglycemia died 8 and 24 hours after occlusion with infarction of the entire middle cerebral artery territory, marked hemispheral edema, and brainstem compression. Our results demonstrate that serum glucose concentration at the time of large cerebral vessel occlusion influences stroke outcome.
Starting Page	51
Ending Page	60
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://stroke.ahajournals.org/content/strokeaha/19/5/623.full.pdf
Alternate Webpage(s)	http://stroke.ahajournals.org/content/strokeaha/19/5/623.full.pdf?origin=publication_detail
Alternate Webpage(s)	http://stroke.ahajournals.org/content/strokeaha/19/5/623.full.pdf?download=true
PubMed reference number	3363596v1
Volume Number	19
Issue Number	5
Journal	Stroke
Language	English
Access Restriction	Open
Subject Keyword	Adjudication Brain Edema Brain Stem Cerebrovascular Occlusion Cerebrovascular accident Cerebrovascular system Cessation of life Compression Hyperglycemia Infarction Occlusion of artery (disorder) Structure of cerebral artery Structure of middle cerebral artery cerebral artery occlusion serum glucose
Content Type	Text
Resource Type	Article

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