NDLI: Reviewer ' s report Title : Zinc finger protein

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Reviewer ' s report Title : Zinc finger protein

Content Provider	Semantic Scholar
Author	Meng, Fanyin
Abstract	In the manuscript submitted by Wang et al, the authors investigated the expression of ZBTB20 in HCC tissues and its potential association with clinicopathological features and post-resectional survival. They observed that increased expression of ZBTB20 in HCC was positively correlated with tumor vein invasion, recurrence and metastasis. Moreover, patients with high intratumoral ZBTB20 expression had significantly worse OS and DFS when compared with patients with low expression of ZBTB20. Multivariate analysis demonstrated that among the factors analyzed, intratumoral ZBTB20 expression was an independent prognostic factor for OS and DFS in patients with HCC. Meanwhile, tumor size, serum AFP, TNM stage, tumor number and vein invasion were all independent prognostic factors for OS; while tumor size, HBsAg positive, TNM stage, tumor number, vein invasion and peritumoral ZBTB20 expression were independent prognostic factors for DFS. These results clearly demonstrated that high ZBTB20 expression is associated with poor progression and unfavorable clinical outcome of HCC. It is reveled that ZBTB20 is overexpressed in a large proportion of patients with HCC and high ZBTB20 expression correlated with the disease progression and poor clinical outcome in HCC. The manuscript is well written and the study is interesting; however, some issues should be addressed before it is eligible for publication.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://static-content.springer.com/openpeerreview/art:10.1186%2F1471-2407-11-271/12885_2011_2763_ReviewerReport_V1_R1.pdf
Alternate Webpage(s)	https://static-content.springer.com/openpeerreview/art:10.1186%2F1471-2407-11-271/12885_2011_2763_ReviewerReport_V1_R2.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Report

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