Copper-Catalyzed Suzuki Biaryl Cross-Coupling of Aryl Halides with Aryl

Content Provider	Semantic Scholar
Author	Tailor, Sanita B. Manzotti, Mattia Asghar, Soneela Rowsell, Benjamin J. S. Luck, Stephen L. J. Sparkesa, Hazel Bedford.a, Robin B.
Copyright Year	2019
Abstract	Intrigued by recent reports on the surprisingly excellent activity of a range of cobalt, iron, copper and nickelbased catalysts in the Suzuki biaryl cross-coupling of simple arylboronic acids with aryl halides, we undertook a reexamination of the syntheses of representative examples of the reported pre-catalysts and their application to the catalytic reaction. A reported PNP-Fe pincer complex, in our hands, proved to be a mixture of starting materials; a mono-Schiff base cobalt complex in fact the bis-ligated adduct and a monomeric copper (II) PNP pincer complex a dior oligomeric copper(I) species. In our hands, neither these complexes, nor any other of the selected pre-catalysts investigated, showed any activity in a Suzuki cross-coupling reaction of an electronically-activated aryl bromide with phenyl boronic acid. Meanwhile, switching the nucleophile to the BuLi-activated phenyl boronic pinacol ester gave some promising activity with cobalt pre-catalysts.
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Alternate Webpage(s)	https://research-information.bris.ac.uk/files/188578050/Full_text_PDF_accepted_author_manuscript_.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article