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Aging Specifically Impairs amnesiac-Dependent Memory in Drosophila
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tamura, Takuya Chiang, Ann-Shyn Ito, Naomi Liu, Hsin-Ping Horiuchi, Junjiro Tully, Tim Saitoe, Minoru |
| Copyright Year | 2003 |
| Abstract | Age-related memory impairment (AMI) is observed in many species. However, it is uncertain whether AMI results from a specific or a nonspecific decay in memory processing. In Drosophila, memory acquired after a single olfactory conditioning paradigm has three distinct phases: short-term memory (STM), middle-term memory (MTM), and longer-lasting anesthesia-resistant memory (ARM). Here, we demonstrate that age-related defects in olfactory memory are identical to those of the MTM mutant amnesiac (amn). Furthermore, amn flies do not exhibit an age-dependent decrease in memory, in contrast to other memory mutants. The absence of AMI in amn flies is restored by expression of an amn transgene predominantly in DPM cells. Thus, we propose that AMI in flies results from a specific decrease in amn-dependent MTM. |
| Starting Page | 1003 |
| Ending Page | 1011 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0896-6273(03)00732-3 |
| PubMed reference number | 14659098 |
| Journal | Medline |
| Volume Number | 40 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0896627303007323 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0896627303007323 |
| Alternate Webpage(s) | http://www.genetics.biozentrum.uni-wuerzburg.de/home/hiromut/paper/amnAging.pdf |
| Alternate Webpage(s) | http://seroudelab.biology.queensu.ca/pdf/tamura.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/S0896-6273%2803%2900732-3 |
| Journal | Neuron |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
