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Accuracy of multi-detector computed tomography, fluorodeoxyglucose positron emission tomography-CT, and CA 19-9 levels in detecting recurrent pancreatic adenocarcinoma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jahromi, A. Hamidian Sangster, Guillermo Pablo Zibari, Gazi B. Martin, Brett Morris Chu, Quyen D. Takalkar, Amol M. Shi, Runhua R. Shokouh-Amiri, Hosein M. |
| Copyright Year | 2013 |
| Abstract | CONTEXT We compared the accuracy of fluorodeoxyglucose positron emission tomography-CT (FDG-PET-CT), multi-detector computed tomography (MDCT) and CA 19-9 levels in detecting pancreatic cancer recurrence in patients with resected CA 19-9 positive pancreatic adenocarcinomas. METHODS We retrospectively evaluated 122 patients with pancreatic adenocarcinomas who underwent surgical resection of the tumor between January 2002 and December 2011. Twenty-five patients had MDCT, FDG-PET-CT and CA 19-9 levels performed no less than six weeks post-operation and within 8 weeks of each other for detection of tumor recurrence. Of these, 20 patients had high pre-operative CA 19-9 levels that dropped to a normal level postoperatively which will be the focus of this study. The sensitivity, specificity, positive and negative predictive value (PPV, NPV), and accuracy of MDCT, FDG-PET-CT, and CA 19-9 in detecting recurrence were compared. RESULTS Operations performed included pyloric sparing pancreaticoduodenectomy (n=9), pancreaticoduodenectomy (n=7), distal pancreatectomy (n=3) and total pancreatectomy (n=1). Three patients had no recurrence, but local recurrence and distant metastasis were seen in 8 (40%) and 12 (60%) patients, respectively. In our study, sensitivity, specificity, PPV, NPV and diagnostic effectiveness (accuracy) were: 82%, 100%, 100%, 50%, 85% for MDCT; 82%, 100%, 100%, 50%, 85% for FDG-PET-CT and 94%, 100%, 100%, 75%, 95% for CA 19-9. The difference in recurrence detection accuracy of the tests was not statistically significant. A combination of CA 19-9 with MDCT or FDG-PET-CT was 100% accurate in detecting cancer recurrence in our patients. CONCLUSION Our data suggests that CA 19-9 levels can be used reliably to detect recurrent pancreatic adenocarcinomas in patients with CA 19-9-positive primary tumors. Combination of CA 19-9 with MDCT or FDG-PET-CT is potentially the most accurate approach in detecting pancreatic cancer recurrence. |
| Starting Page | 1441 |
| Ending Page | 1442 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.serena.unina.it/index.php/jop/article/download/1529/1797 |
| PubMed reference number | 23846950v1 |
| Alternate Webpage(s) | https://doi.org/10.6092/1590-8577/1529 |
| DOI | 10.6092/1590-8577/1529 |
| Journal | JOP : Journal of the pancreas |
| Volume Number | 14 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biliopancreatic Diversion Detectors Distal Pancreatectomy Distant Metastasis Excision Fluorodeoxyglucose F18 Negative Predictive Value of Diagnostic Test Neoplasms Nucleopolyhedrovirus Numerous PET/CT scan Pancreatic adenocarcinoma Pancreatic carcinoma Pancreaticoduodenectomy Patients Pet Therapy Positrons Pylorus Recurrent tumor Structure of delta Cell of islet Tomography, Spiral Computed Total pancreatectomy X-Ray Computed Tomography primary tumor |
| Content Type | Text |
| Resource Type | Article |
